Cranberries, a hallmark of the Thanksgiving meal, take center stage in this festive, big-batch take on a Moscow Mule. For a nonalcoholic option, use seltzer instead of vodka.
Stir together sugar, cranberries, orange slices, and 1/2 cup water in a small saucepan. Cook over medium-high, stirring occasionally, until cranberries just start to burst, about 5 minutes. Remove from heat; let cool completely. Remove orange slices; discard. Refrigerate until cold, at least 1 hour and up to 1 week.
In a pitcher, combine syrup, vodka, lime juice, and ginger beer. Serve over crushed ice, with mint and fresh orange slices.